Felodipine and Grapefruit: What You Need to Know About This Dangerous Mix

When you take felodipine, a calcium channel blocker used to treat high blood pressure. Also known as Plendil, it works by relaxing your blood vessels so your heart doesn’t have to work as hard. But if you eat grapefruit or drink grapefruit juice, you’re not just adding flavor to your breakfast—you’re risking a dangerous spike in medication levels. This isn’t a myth. It’s a well-documented interaction that can lead to dizziness, fainting, or even a heart attack.

The problem lies in how your body breaks down felodipine. It’s processed by an enzyme called CYP3A4, found mostly in your gut. Grapefruit contains chemicals that shut down this enzyme. When that happens, your body can’t clear felodipine the way it should. The result? More of the drug stays in your bloodstream, turning a normal dose into an overdose. This isn’t just about grapefruit juice—it’s also about fresh fruit, frozen pulp, and even some flavored sodas. One glass can affect you for up to 72 hours.

This interaction isn’t unique to felodipine. It’s the same reason you’re warned about statins, some anti-anxiety meds, and even certain heart rhythm drugs. But with felodipine, the risk is especially high because it’s already a potent blood pressure reducer. Combine that with grapefruit, and your blood pressure can drop too far, too fast. Older adults, people with liver issues, or those on multiple heart meds are at the greatest risk. You don’t need to be a medical expert to understand this: if your prescription says to avoid grapefruit, don’t test it.

What can you drink instead? Orange juice is fine—unless it’s Seville or bitter orange, which act the same way. Apple juice, cranberry juice, and water are safe bets. If you love citrus, stick to regular oranges or tangerines. And if you’re unsure whether your meds interact with grapefruit, check the label or ask your pharmacist. Most pharmacies now flag this risk when you pick up your prescription.

The posts below cover real cases and comparisons you won’t find in a drug brochure. You’ll see how grapefruit messes with other heart meds like statins and blood thinners, why some people get hit harder than others, and what to do if you accidentally mixed them. You’ll also learn how to spot hidden sources of grapefruit in processed foods and supplements. This isn’t about fear—it’s about control. Knowing what to avoid gives you real power over your health.